Alzheimer May be Insulin-Dependent Disease -
Alzheimer May be Insulin-Dependent Disease - CME Teaching Brief - MedPage Today: "MedPage Today Action Points
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PROVIDENCE, R.I., Nov. 30 - Insulin and associated signaling molecules begin to disappear from the brain during early Alzheimer's, suggesting the possibility of therapy to boost levels of insulin in the brain, researchers here reported. They call Alzheimer's 'type 3 diabetes.'
Mean levels of insulin, the signaling molecule insulin-like growth factor I (IGF-I), and its receptor decline significantly in the brain during the early stages of Alzheimer's, compared with normal controls, and decrease by 80% or more in late-stage disease, according to Suzanne M. de la Monte, M.D., and colleagues at Brown Medical School here. "/.../
Review
PROVIDENCE, R.I., Nov. 30 - Insulin and associated signaling molecules begin to disappear from the brain during early Alzheimer's, suggesting the possibility of therapy to boost levels of insulin in the brain, researchers here reported. They call Alzheimer's 'type 3 diabetes.'
Mean levels of insulin, the signaling molecule insulin-like growth factor I (IGF-I), and its receptor decline significantly in the brain during the early stages of Alzheimer's, compared with normal controls, and decrease by 80% or more in late-stage disease, according to Suzanne M. de la Monte, M.D., and colleagues at Brown Medical School here. "/.../
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